SIBCR's mission is to improve the health and well-being of Veterans through research and education conducted at both the Seattle and Tacoma VA Puget Sound Health Care System. SIBCR is dedicated to supporting research and education efforts by facilitating collaborative research projects with other federal agencies, voluntary health organizations, nonprofit professional societies, academic institutions and for-profit companies.
Equal Employment Opportunity Policy
The Seattle Institute for Biomedical and Clinical Research does not discriminate in employment on the basis of race, color, religion, sex (including pregnancy and gender identity), national origin, political affiliation, sexual orientation, marital status, disability, genetic information, age, membership in an employee organization, retaliation, parental status, military service, or other non-merit factor. Click here for more information from EEOC | E-Verify Participant | Immigrant and Employee Rights
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Date Posted: 1/6/2020
The laboratory of Brian Kraemer seeks a talented and enthusiastic postdoc who works well with others to join our multi-disciplinary collaborative research team at the Seattle Institute for Biomedical and Clinical Research (SIBCR). Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. The Kraemer laboratory studies the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a full time position working on a research project supported by an NIH funded R01 grant.
We offer: a highly stimulating and collaborative scientific work environment in a large laboratory with state of the art research equipment and cutting edge microscopy facilities. Opportunities for career development are readily available and include access to the NIH sponsored Alzheimer’s Disease and related dementia training program. This position includes full benefits and compensation at the NIH stipulated pay scale for postdocs. Seattle is a dynamic city in the Pacific Northwest with easy access to both the cascade mountains and Puget Sound. Additional information about the laboratory and research setting can be found here: https://sites.google.com/uw.edu/kraemerlab/home
- A PhD in a relevant field of the biomedical science.
- Experience designing and executing well controlled experiments.
- Strong writing skills.
- Strong verbal communication skills.
- Ability to work both independently and as a cooperative part of a team.
- Authorized to work in the US
Beneficial experience/knowledge/skills may include:
- Experience in genome editing using CRIPSR/Cas9 methods.
- Experience in molecular cloning and transgenesis methods
- Experience with genetic analysis methods in model organisms.
- Experience in assessing protein aggregation.
- Experience in advanced microscopy techniques.
- Knowledge of RNA binding protein function.
- Knowledge of the pathobiology of neurodegenerative disease
- Knowledge of the biology of aging and disease
- Knowledge of neurobiology
Date Posted: 10/13/2020
This is a full-time position in a laboratory devoted to the development and implementation of fluorine-18 and/or carbon-11 radioligands for use in positron emission tomography (PET) imaging studies supporting central nervous system (CNS) drug development and investigations of the neurobiology of brain diseases.
The Research Associate I will be responsible for the day to day operations of the radioligand development research lab, assist in and carry out chemical syntheses and instrumental analyses of cold (non-radiolabeled) compounds under the direction of the PhD radiochemist. The Research Associate I will also conduct analyses of radiolabeled compounds in rodent brain tissue and blood samples, and conduct analyses of radioactivity in blood samples obtained from human subjects during PET brain imaging studies under the direction of the investigators.
Seattle is a dynamic city in the Pacific Northwest with easy access to both the Cascade mountains and Puget Sound.
- Ordering supplies & equipment; tracking inventory
- General laboratory maintenance (lab organization and cleaning, equipment maintenance, preparing for inspections, following disposal protocols); help organize and track study samples, and record and archive paper and electronic data
- Assist with organic chemical synthesis (conduct organic chemical synthesis procedures, prepare stock solutions, clean glassware, chemical waste collection and regulated disposal)
- Preferred: Able to independently carry out organic synthesis
Able to handle moisture and air sensitive reagents for organic synthesis
- Purification and instrumental analysis of organic compounds (TLC, column chromatography, HPLC, NMR)
- Process harvested brain and organ tissues from rodents (rats & mice)
- Work with animal and human specimens of blood and tissues
- Work with radioactively labeled compounds and specimens
- Other duties as assigned
- Bachelor’s degree or higher in an appropriate field of technology or science; Master’s degree or higher is preferred
- At least two years full-time research experience, three to five years preferred
- Basic knowledge of computers for word processing, graphic presentation, and using laboratory equipment
- Strong organizational, analytic, and writing and verbal communication skills
- Able to work with members of a scientific team
- Able to keep detailed notes of experiments
- Willing to learn new techniques
- Willing to work with radioactivity
- Willing to assist with animal experimental protocols
Knowledge and Experience:
- Experience with HPLC
- Experience in organic synthetic chemistry
- Knowledge or experience with radiochemical synthesis preferred
Date Posted: 10/13/2020
The full time Laboratory Technician will be responsible for the day to day operations of the metabolism research lab. This lab studies the neuropeptide oxytocin decreases both food intake and body weight, and carries the potential to serve as a therapeutic agent in combating metabolic conditions such as obesity. However, the underlying physiology that contributes to these effects remains largely unknown. Studies in our lab aim to dissect the role of oxytocin in the pathogenesis of diet-induced obesity in rodents. The Blevin’s lab is interested in defining the role of reductions in oxytocin signaling in the progression of diet-induced obesity as well as whether increased oxytocin signaling is an effective strategy to circumvent leptin resistance and reduce body weight gain in diet-induced obese rodents.
- Ordering supplies
- Manage grant budget
- Plan experiments
- Prepare tests and collect data per research protocol
- Handle rats and mice, measure food intake, body weight, and collect tissue
- Aspects of immunocytochemistry, fluorescence microscopy, mouse breeding, and RT-PCR
- Animal work will include: stereotaxic surgeries (third and fourth ventricular cannulations), subcutaneous minipump implantations, brown fat temperature transponder implantation, post-operative care and monitoring post-operative care and monitoring, daily food intake and body weight measurements, brown fat temperature measurements, subcutaneous and intraperitoneal injections, acute injections of drugs into the third or fourth ventricle and acute adeno-associated virus administration into the hypothalamus and hindbrain
- Other duties as assigned
- BS degree in biology, neuroscience, biochemistry or chemistry
- Strong organizational, analytic, and communication skills
Knowledge and Experience:
- Experience with immunocytochemistry and stereotaxic surgery
- Experience with PCR
- Ability to handle rates and mice
Date Posted: 10/27/2020
The Research Study Coordinator/ Program manager will manage a series of studies based at the Seattle VA Medical Center. This position will require an individual who understands the principles of scientific investigation and clinical trials, who is capable of in-depth understanding of the study protocol and is able to make complex decisions independently. The candidate must possess strong scientific, organizational, and interpersonal skills. A BA/BS or higher is required; a degree in scientific research-related field is strongly recommended. The position is full-time; Monday through Friday approximately 8:00 – 4:30 pm. The salary is based on the applicant’s research experience and includes benefits.
- Develop and execute funded study protocol while ensuring compliance with the study protocol and Institutional Review Board guidelines.
- Coordinate regulatory audits of the study ensuring organization of study records and compliance with regulations.
- Develop procedures and manage a team for purpose of recruitment of study participants and acquisition of study data.
- Coordinate among cross-functional teams including the study sponsor, study sites, medical center administrative and clinical staff, research monitors, patients and enrolled subjects.
- Develop and enact methods to ensure quality control of study data and sharing of data across study sites in compliance with all required protocols and directives.
- Design and maintain study databases and files.
- Perform data analyses of patient characteristics and outcomes for the Senior Investigator (PI) for inclusion in reports and manuscripts.
- Develop and maintain a study budget, tracking expenditures and providing reports as requested.
- Assist with grant submissions, including preparing applications, conducting literature reviews, and other tasks as needed.
- BA/BS and 2+ years of experience in health research
- Experience with electronic medical record systems
- Knowledge of research compliance regulations
- Experience using the Microsoft Outlook, Word, Excel, Access
Desirable Knowledge and Experience:
- Experience using SQL, STATA, or other data management and statistical software package
- At least two years of team management experience.