SIBCR's mission is to improve the health and well-being of Veterans through research and education conducted at both the Seattle and Tacoma VA Puget Sound Health Care System. SIBCR is dedicated to supporting research and education efforts by facilitating collaborative research projects with other federal agencies, voluntary health organizations, nonprofit professional societies, academic institutions and for-profit companies.

SIBCR is an Equal Opportunity Employer. No phone calls please.

Go to: Postdoctoral Scholar - NDR | Research Assistant - EM1 | Research Associate - ME1 | Research Coordinator/Assistant - ZC1 | Laboratory Technician - BW1 | Postdoctoral Researcher (Erickson/Banks)

 

Date Posted: 9/25/18

Full-time, Exempt/Salary

How to apply

POSTDOCTORAL FELLOW - GJ1

The Garcia laboratory in the Department of Medicine at the University of Washington and the VA Puget Sound is looking for a highly motivated postdoctoral fellow, who is interested in studying signaling networks related to mitochondria and muscle wasting in cancer patients and in skeletal muscle samples.

The research team is interested in elucidating comprehensive signaling networks that control muscle mass and function with the goals to identify and characterizing novel mechanisms of muscle atrophy in the setting of cancer. We are particularly interested in the role of mitochondria and hormonal signaling including androgens.

Required:
Applicants should have a Ph.D. degree or equivalent in the field of the life sciences, a strong publication record, and good spoken/written communication skills.

Highly desirable:
Backgrounds/skills include expertise in: 1) Clinical/translational research, 2) Muscle metabolism and mitochondrial function, and 3) molecular biology in cancer or metabolic diseases. The postdoctoral fellow will work in a highly interactive laboratory environment and collaborate with clinical experts, molecular biologists, and biochemists.

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Date Posted: 1/6/2020

Full time/Non-exempt

How to apply

POSTDOCTORAL SCHOLAR IN NEURODEGENERATIVE DISEASE RESEARCH

SUMMARY:

The laboratory of Brian Kraemer seeks a talented and enthusiastic postdoc who works well with others to join our multi-disciplinary collaborative research team at the Seattle Institute for Biomedical and Clinical Research (SIBCR). Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. The Kraemer laboratory studies the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a full time position working on a research project supported by an NIH funded R01 grant.

We offer: a highly stimulating and collaborative scientific work environment in a large laboratory with state of the art research equipment and cutting edge microscopy facilities. Opportunities for career development are readily available and include access to the NIH sponsored Alzheimer’s Disease and related dementia training program. This position includes full benefits and compensation at the NIH stipulated pay scale for postdocs. Seattle is a dynamic city in the Pacific Northwest with easy access to both the cascade mountains and Puget Sound. Additional information about the laboratory and research setting can be found here: https://sites.google.com/uw.edu/kraemerlab/home 

Required Qualifications:

  • A PhD in a relevant field of the biomedical science.
  • Experience designing and executing well controlled experiments.
  • Strong writing skills.
  • Strong verbal communication skills.
  • Ability to work both independently and as a cooperative part of a team.
  • Authorized to work in the US

Beneficial experience/knowledge/skills may include:

  • Experience in genome editing using CRIPSR/Cas9 methods.
  • Experience in molecular cloning and transgenesis methods
  • Experience with genetic analysis methods in model organisms.
  • Experience in assessing protein aggregation.
  • Experience in advanced microscopy techniques.
  • Knowledge of RNA binding protein function.
  • Knowledge of the pathobiology of neurodegenerative disease
  • Knowledge of the biology of aging and disease
  • Knowledge of neurobiology

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Date Posted: 1/6/2020

Full time/Non-exempt

How to apply

RESEARCH ASSISTANT - EM1

Summary:
This posting is for a research assistant position in the labs of Drs. Michelle A. Erickson and William A. Banks at the Seattle VA Medical Center. The scientific focus of the labs comprises many aspects of blood-brain barrier physiology that include peptide and protein transport, neuroimmune communication, and perturbation by pharmacologic agents, inhaled toxicants, and disease states such as Alzheimer’s disease. This position is temporary (1-2 years), with extension/renewal possible depending on the applicant’s performance, lab needs, and funding. Applicants who wish to gain post-baccalaureate research experience to strengthen their application for an advanced degree program would be well-suited for this position.

Responsibilities:

  • Carry out technical aspects of research projects, which includes designing and conducting experiments, recording and managing data, and communicating results to supervisors and the research group
  • Complete and stay current on all training required by the VA and affiliated institutions and adhere to all rules and regulations
  • More detailed aspects of technical duties:
    • Maintain cell cultures, including iPSC lines and in vitro models of the blood-brain barrier
    • Conduct pharmacokinetic studies of peptide and protein transport across the blood-brain barrier in vitro and in vivo
    • Assist with tissue dissections and sample processing
    • Quantify levels of proteins and mRNA in tissues using procedures such as immunoblotting, ELISA, immunofluorescent analysis and microscopy, qPCR, etc.

Position Requirements:

  • Must be able to commit 40 hours a week
  • Must be willing to occasionally work evenings and weekends when needed
  • Must be willing to work with mice and radioactive isotopes and strictly adhere to all regulations regarding their use
  • Must be authorized to work in the United States
  • Must work well with others, be pro-active about seeking help when needed, and respect all members in the lab

Knowledge and Experience:

  • Bachelor’s degree in biology or a related academic program in the life sciences (exceptional candidates in their senior year with a low burden of coursework may be considered). Please include unofficial transcript with coverletter and resume.
  • Prior wet lab experience, including cell culture and experience with molecular biology techniques preferred.

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Date Posted: 1/13/2020

Full time/Non-exempt

How to apply

RESEARCH ASSOCIATE - ME1

Summary:
Seeking experienced research technician for molecular biology position that utilizes patient samples, cell lines, and xenograft models for investigation of prostate cancer. Looking for an applicant with specific expertise/background in tissue culture, establishment of organoids, histology, and cell imaging techniques. Experience in murine handling, tumor xenografting, and laboratory management is desirable. The position requires experience or willingness to participate in preparing, submitting and monitoring IACUC and Biohazard protocols. Holiday or weekend work may occasionally be required.

Responsibilities:
Work independently under the direction of the Principal Investigator. Use discretion and judgment in carrying out experiments. May lead or supervise other laboratory personnel and be responsible for the daily operation of the laboratory.

  • Perform experiments at the bench level to support investigative work.
  • Identify methodological problems in research protocol and implement modifications to optimize experimental results.
  • Assist in the design of experiments. Conduct literature reviews to assist in determining most suitable methods to be used in research. Interact with collaborators for technique optimization.
  • Prepare and present progress reports including assembly, organization, statistical analysis and interpretation of data. Assist in publication of results by proofreading, editing, and contributing ideas.
  • Oversee preparation and maintenance of laboratory reagents, stocks, cultures or cell lines.
  • Oversee operation and carry out basic maintenance of laboratory equipment. Oversee ordering and maintenance of appropriate levels of supplies.

Position Requirements:
A bachelor’s or master’s degree in a biological science and a minimum of four to six years of research experience (depending on academic degree) with molecular and cellular techniques are required. Must be capable of working in a highly independent environment. Must have strong interpersonal skills and ability to work with others, strong organizational and written skills, and excellent attention to detail.

Knowledge and Experience:

  • Cell Culture. Experience in sterile technique and growth and passage of cell-lines, mycoplasma testing, performance of proliferation, apoptosis and other cellular assays required. Experience in establishment of organoid cultures desirable.
  • Histology and cell imaging. Experience in tissue processing, embedding tissue for histologic processing, cryostat and microtome tissue sectioning and experience in histochemical staining of tissues. Expertise in live cell fixation and imaging techniques for in vitro cultures and organoids.
  • Molecular Biology. DNA isolation, DNA sequencing and cloning. Experience with stable and transient knockdown and over expression techniques, inducible systems and lentiviral approaches. Protein isolation and analysis including immunoprecipitation and Western blot analysis. RNA isolation and purification for generation of RNAseq libraries, design of primers and performance of quantitative real-time PCR.
  • Murine Models. Experience in mouse handling, administration of drugs via oral gavage, xenograft tumor monitoring, and surgical techniques desirable.
  • Software. Proficient in Microsoft Office (Outlook, Excel, Word, and PowerPoint) and other statistical programs for data collection and analysis.

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Date Posted: 1/13/2020

Full time/Non-exempt

How to apply

RESEARCH COORDINATOR/ASSISTANT - ZC1

General Duties/Description:
The Research Coordinator/Assistant (DOE) will play an integral role in ongoing, multicenter research studies on Parkinson’s disease and Lewy Body Dementias based at the Seattle VA Medical Center. This individual will participate in subject screening and recruitment, collection of clinical information, procurement of biological specimens, medical records review, and data coding/entry. Travel offsite may be required periodically.

Under minimal supervision, this individual will:

  • Screen subjects for eligibility criteria
  • Obtain informed consent from study participants
  • Collect clinical information from interviews with study participants
  • Conduct neuropsychological testing and gait assessment
  • Enter clinical information and test results into databases
  • Perform venipuncture and assist lumbar punctureProcess biospecimen
  • Schedule visits for study participants
  • Communicate with the IRB for study procedures and modifications
  • Coordinate projects with other research groups
  • Maintain contact with physicians and community organizations for recruitment

Requirement:

Bachelor’s degree in relevant academic areas and experience working in human subjects research.

Desirable:

  • Experience with psychometric testing
  • Experience working with Institutional Review Boards
  • Experience with geriatric populations, particularly patients with neurodegenerative disorders
  • Educational or working knowledge of neurobiology and genetics
  • Ability to work independently, strong interpersonal skills
  • A strong working knowledge of Microsoft Access and Excel software

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Date Posted: 1/28/20

Full time/Non-exempt

How to apply

LABORATORY TECHNICIAN - WB1

Summary:


The full time Laboratory Technician will be responsible for the day to day operations of a basic science laboratory specializing in blood-brain barrier. The technician will conduct experiments on rats and mice both independently and in collaboration with others and be responsible for the instruction and supervision of graduate students, post docs, and in some cases junior faculty. The position also includes writing animal protocols, ordering supplies, other aspects of lab maintenance, some administrative duties, basic statistical and pharmacokinetic analysis, and assisting with preparation of grants and scientific manuscripts.

Responsibilities:

  • Order supplies
  • Manage grant budget
  • Plan experiments
  • Label and purify radioactive ligands
  • Prepare tests and collect data per research protocol
  • Handle rats and mice, measure food intake, body weight, and collect tissue
  • Aspects of immunocytochemistry, fluorescence microscopy, and mouse breeding
  • Animal work will include: stereotaxic surgeries (for example controlled cortical impact), subcutaneous minipump implantations, small animal surgical techniques (isolation of carotid arteries), post-operative care and monitoring post-operative care and monitoring, brain dissections
  • Other duties as assigned

Position Requirements:

  • BS degree in biology, neuroscience, biochemistry or chemistry
  • Strong organizational, analytic, and communication skills

Knowledge and Experience:

  • Experience with small animal surgery and ability to handle rats and mice
  • Comfortable with handling low levels of radioactive materials
  • General lab skills

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Date Posted: 1/28/20

Full time/Non-exempt

How to apply

 

POSTDOCTORAL RESEARCHER - in vitro blood-brain barrier dysfunction (Erickson/Banks)

Summary:

This posting is for a postdoctoral position in the labs of Drs. Michelle A. Erickson and William A. Banks at the Seattle VA Medical Center and University of Washington. The scientific focus of the labs comprises many aspects of blood-brain barrier physiology that include peptide and protein transport, neuroimmune communication, and effects of disease states on blood-brain barrier functions. The candidate would be expected to support a project which aims to determine how circulating factors contribute to blood-brain barrier dysfunction in aging and Alzheimer’s disease. The candidate would also be encouraged to participate on other projects that align with their goals for career development. This position is supported by strong funding from the VA and NIH. The VA Medical Center and University of Washington offer a tremendous training environment for postdoctoral researchers interested in the fields of neuroscience, stem cell biology, aging, and Alzheimer’s disease.

Responsibilities:

  • Carry out technical aspects of research projects, which include designing and conducting experiments, recording and analyzing data, and communicating results to supervisors and the research group at least weekly
  • Maintain inventory of human induced pluripotent stem cell (iPSC) lines and human primary glial cell
  • Conduct routine differentiations of iPSCs into brain endothelial-like cells to support ongoing projects in the lab
  • Complete and stay current on all training required by the VA and affiliated institutions, adhere to all rules and regulations
  • Assist in the writing and submission of regulatory documents
  • Supervise junior investigators at undergraduate level or above
  • Apply for postdoctoral fellowships and/or career development awards such as those supported by the VA or NIH
  • Present data at scientific conferences
  • Prepare manuscripts on original research and write literature reviews
  • More detailed aspects of technical duties:
    • Maintain cell cultures, including iPSC lines and in vitro models of the blood-brain barrier, primary glia, etc.
    • Conduct pharmacokinetic studies of peptide and protein transport across the blood-brain barrier in vitro and in vivo
    • Dissect tissues and process tissue samples for analysis
    • Quantify levels of proteins and mRNA in tissues using procedures such as immunoblotting, ELISA, immunofluorescent analysis and microscopy, qPCR, etc.
    • Learn and apply new techniques (including SOPs) to ongoing projects.

Position Requirements:

  • Ph.D., M.D., or other doctoral degree with experience in neuroscience, pharmacology, physiology, immunology, or a related field in the biomedical sciences (degree must be completed by Fall 2020).
  • Eligible to work in the U.S. and to apply for T32/F32 funding
  • At least 3 years of cell culture experience, work with primary neuronal and glial cultures and/or iPSCs is preferred
  • Able to work with mice and radioactive isotopes
  • Able to work alternating weekends for tissue culture maintenance
  • Must work well with others, maintain meticulous records, be pro-active about seeking help when needed, and treat all lab members with respect
  • Experience with techniques such as RNAseq, proteomics, metabolomics, flow cytometry, 3D tissue culture, etc. is beneficial, but not strictly required.

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