SIBCR's mission is to improve the health and well-being of Veterans through research and education conducted at both the Seattle and Tacoma VA Puget Sound Health Care System. SIBCR is dedicated to supporting research and education efforts by facilitating collaborative research projects with other federal agencies, voluntary health organizations, nonprofit professional societies, academic institutions and for-profit companies.
SIBCR is an Equal Opportunity Employer. No phone calls please.
Date Posted: 1/6/2020
The laboratory of Brian Kraemer seeks a talented and enthusiastic postdoc who works well with others to join our multi-disciplinary collaborative research team at the Seattle Institute for Biomedical and Clinical Research (SIBCR). Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. The Kraemer laboratory studies the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a full time position working on a research project supported by an NIH funded R01 grant.
We offer: a highly stimulating and collaborative scientific work environment in a large laboratory with state of the art research equipment and cutting edge microscopy facilities. Opportunities for career development are readily available and include access to the NIH sponsored Alzheimer’s Disease and related dementia training program. This position includes full benefits and compensation at the NIH stipulated pay scale for postdocs. Seattle is a dynamic city in the Pacific Northwest with easy access to both the cascade mountains and Puget Sound. Additional information about the laboratory and research setting can be found here: https://sites.google.com/uw.edu/kraemerlab/home
- A PhD in a relevant field of the biomedical science.
- Experience designing and executing well controlled experiments.
- Strong writing skills.
- Strong verbal communication skills.
- Ability to work both independently and as a cooperative part of a team.
- Authorized to work in the US
Beneficial experience/knowledge/skills may include:
- Experience in genome editing using CRIPSR/Cas9 methods.
- Experience in molecular cloning and transgenesis methods
- Experience with genetic analysis methods in model organisms.
- Experience in assessing protein aggregation.
- Experience in advanced microscopy techniques.
- Knowledge of RNA binding protein function.
- Knowledge of the pathobiology of neurodegenerative disease
- Knowledge of the biology of aging and disease
- Knowledge of neurobiology
Date Posted: 1/28/20
This posting is for a postdoctoral position in the labs of Drs. Michelle A. Erickson and William A. Banks at the Seattle VA Medical Center and University of Washington. The scientific focus of the labs comprises many aspects of blood-brain barrier physiology that include peptide and protein transport, neuroimmune communication, and effects of disease states on blood-brain barrier functions. The candidate would be expected to support a project which aims to determine how circulating factors contribute to blood-brain barrier dysfunction in aging and Alzheimer’s disease. The candidate would also be encouraged to participate on other projects that align with their goals for career development. This position is supported by strong funding from the VA and NIH. The VA Medical Center and University of Washington offer a tremendous training environment for postdoctoral researchers interested in the fields of neuroscience, stem cell biology, aging, and Alzheimer’s disease.
- Carry out technical aspects of research projects, which include designing and conducting experiments, recording and analyzing data, and communicating results to supervisors and the research group at least weekly
- Maintain inventory of human induced pluripotent stem cell (iPSC) lines and human primary glial cell
- Conduct routine differentiations of iPSCs into brain endothelial-like cells to support ongoing projects in the lab
- Complete and stay current on all training required by the VA and affiliated institutions, adhere to all rules and regulations
- Assist in the writing and submission of regulatory documents
- Supervise junior investigators at undergraduate level or above
- Apply for postdoctoral fellowships and/or career development awards such as those supported by the VA or NIH
- Present data at scientific conferences
- Prepare manuscripts on original research and write literature reviews
- More detailed aspects of technical duties:
- Maintain cell cultures, including iPSC lines and in vitro models of the blood-brain barrier, primary glia, etc.
- Conduct pharmacokinetic studies of peptide and protein transport across the blood-brain barrier in vitro and in vivo
- Dissect tissues and process tissue samples for analysis
- Quantify levels of proteins and mRNA in tissues using procedures such as immunoblotting, ELISA, immunofluorescent analysis and microscopy, qPCR, etc.
- Learn and apply new techniques (including SOPs) to ongoing projects.
- Ph.D., M.D., or other doctoral degree with experience in neuroscience, pharmacology, physiology, immunology, or a related field in the biomedical sciences (degree must be completed by Fall 2020).
- Eligible to work in the U.S. and to apply for T32/F32 funding
- At least 3 years of cell culture experience, work with primary neuronal and glial cultures and/or iPSCs is preferred
- Able to work with mice and radioactive isotopes
- Able to work alternating weekends for tissue culture maintenance
- Must work well with others, maintain meticulous records, be pro-active about seeking help when needed, and treat all lab members with respect
- Experience with techniques such as RNAseq, proteomics, metabolomics, flow cytometry, 3D tissue culture, etc. is beneficial, but not strictly required.
Date Posted: 3/26/2020
Duties assigned to this title will require an in depth knowledge of a specialized field, process, or discipline and may involve organizing and implementing complex research plans, the development of methods of research, testing and data collection, analysis and evaluation, and writing reports containing descriptive, analytical, and evaluative content. The duties will require the exercise of independent discretion and judgment in carrying out research activities within the predetermined research scope and methodology.
- Knowledge of the principles and techniques of the subject disciplines.
- Organizational and project management skills.
- Written and oral communication skills.
- The incumbent will be employed to carry out advanced independent and/or directed research to achieve the objectives of the research project.
- At the time of employment, the responsible faculty member or principal investigator will establish the professional objectives and performance standards for the incumbent and will make annual evaluations.
- Collect and analyze data, including periodical/literature search and utilizing specialized skills in related field to analyze the collected data.
- Participate/assist in manuscript writing for publication in scientific journals and/or presentations. May also assist in grant writing.
- Presentation of project results to internal and external parties.
- Lab maintenance, including equipment maintenance, and ordering of supplies as needed.
- Other duties as assigned, which may include attending Scientific Conferences and Meetings.
- A doctoral degree in the appropriate field or discipline.
- Must provide three professional references
Date Posted: 7/10/2020
The Research Technician will work in a large, successful group focused on muscle wasting research. Responsibilities will include working both independently and as a member of a team with multiple technicians, post-doctoral fellows and principal investigators, and providing technical assistance with ongoing research projects. Duties will focus on managing mouse colonies, performing animal physiology studies and ex-vivo work with rodent and human samples.
- Monitor mouse colonies and perform experiments in rodents related to muscle wasting.
- Be responsible for mouse breeding, including genotyping.
- Perform tissue collection and prepare tissue for subsequent analysis (e.g. histology, biochemical assay).
- Performance of molecular assays (PC, western, ELISA, immunohistochemistry) in tissue samples.
- Perform regular presentations of data to the research group.
- Provide general up keep in the laboratory.
- Perform other related duties as assigned.
- Maintanence of training and certifcations as required by the facility.
- Training is provided and after further training more duties and responsibilities to be
Bachelor's degree in physiology or related field. This job requires the individual to be motivated, well organized and have good attention to detail. Experience in cell culture, immunostaining and histology would be beneficial. Proficiency in using Microsoft Office, particularly design and use of spreadsheets is desirable.
The person in the Research Technician position must be willing to work 20-40 hours/week, on a five day/week (M-F) daytime schedule with occasional weekend or evening hours as needed.
Knowledge and Experience:
One to three years of relevant experience with research mice.
Date Posted: 7/29/2020
Seattle Institute for Biomedical and Clinical Research at the VA Puget Sound Health Care System has an outstanding opportunity for a master’s-level biostatistician to work with an experienced group of investigators committed to high-quality research at the Geriatric Research Education and Clinical Center (GRECC). This individual will support and collaborate with GRECC researchers on epidemiological, clinical, and genetic studies of neurodegenerative and psychiatric disorders (e.g., Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury). Primary scientific responsibilities will be the application of statistics to observational health research including the design, analysis, interpretation, and documentation phases.
- Work with the senior PhD biostatistician, medical investigators, and research associates to design, analyze, and present/publish results of biomarker, epidemiological, and genetic studies related to neurodegenerative and psychiatric disorders.
- Work with researchers to identify relevant research questions and appropriate analysis design.
- Work with research associates to extract and create databases for statistical analysis.
- Implement and program statistical software for data cleaning and data analysis.
- Work with research associates and medical investigators to ensure high data quality.
- Document, present, and explain statistical analyses.
- Collaborate with GRECC researchers on manuscripts, posters, and other presentations of results.
- Collaborate with GRECC researchers to identify new topics for investigation.
- MS degree in biostatistics, statistics, or closely related field, and at least 3 years of experience post degree.
- Experience with research design, data collection, and data analysis.
- Proficient in the statistical software package R. (Experience with SPSS and/or Python a plus.)
- Excellent programming skills.
- Proficient with MS EXCEL and MS Word.
- Ability to work with a diverse group of researchers with varying levels of statistical and research experience.
- Ability to work independently and with limited supervision.
- Flexible with changing priorities and timelines.
- Excellent verbal and written communication skills.
- Strong interpersonal skills.
- Background in biological sciences and experience in statistical genetics a plus.
- Must pass background check; VA Puget Sound Health Care System requires candidate to be a US Citizen, green card holder, or have permanent resident status (SIBCR does not sponsor VISAs).
Date Posted: 8/6/2020
- Prepare tests and collect data per research protocol
- Handle rats and mice, measure food intake, body weight, perform stereotaxic surgery, and collect tissue.
- Duties may also include aspects of immunocytochemistry, fluorescence microscopy, mouse breeding and RT-PCR.
- Ability/experience with handling rats and mice a plus.
- Minimum Bachelor’s degree in biology, neuroscience, biochemistry, or chemistry.
- Demonstrated strong verbal and written communication skills, attention to detail, highly organized and work independently as part of a collaborative team.