SIBCR's mission is to improve the health and well-being of Veterans through research and education conducted at both the Seattle and Tacoma VA Puget Sound Health Care System. SIBCR is dedicated to supporting research and education efforts by facilitating collaborative research projects with other federal agencies, voluntary health organizations, nonprofit professional societies, academic institutions and for-profit companies.

SIBCR is an Equal Opportunity Employer. No phone calls please.

Go to: Postdoctoral Scholar - NDR | Laboratory Technician - BW2 | Laboratory Technician II - BW2 | Postdoctoral Researcher (Erickson/Banks) | Research Study Assistant - MIRECCBiostatistician - GRECC | Research Grants Manager | Research Grants Speicialist | Postdoctoral Clinical Research Fellow

 

Date Posted: 1/6/2020

Full time/Non-exempt

How to apply

POSTDOCTORAL SCHOLAR IN NEURODEGENERATIVE DISEASE RESEARCH

SUMMARY:

The laboratory of Brian Kraemer seeks a talented and enthusiastic postdoc who works well with others to join our multi-disciplinary collaborative research team at the Seattle Institute for Biomedical and Clinical Research (SIBCR). Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. The Kraemer laboratory studies the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a full time position working on a research project supported by an NIH funded R01 grant.

We offer: a highly stimulating and collaborative scientific work environment in a large laboratory with state of the art research equipment and cutting edge microscopy facilities. Opportunities for career development are readily available and include access to the NIH sponsored Alzheimer’s Disease and related dementia training program. This position includes full benefits and compensation at the NIH stipulated pay scale for postdocs. Seattle is a dynamic city in the Pacific Northwest with easy access to both the cascade mountains and Puget Sound. Additional information about the laboratory and research setting can be found here: https://sites.google.com/uw.edu/kraemerlab/home 

Required Qualifications:

  • A PhD in a relevant field of the biomedical science.
  • Experience designing and executing well controlled experiments.
  • Strong writing skills.
  • Strong verbal communication skills.
  • Ability to work both independently and as a cooperative part of a team.
  • Authorized to work in the US

Beneficial experience/knowledge/skills may include:

  • Experience in genome editing using CRIPSR/Cas9 methods.
  • Experience in molecular cloning and transgenesis methods
  • Experience with genetic analysis methods in model organisms.
  • Experience in assessing protein aggregation.
  • Experience in advanced microscopy techniques.
  • Knowledge of RNA binding protein function.
  • Knowledge of the pathobiology of neurodegenerative disease
  • Knowledge of the biology of aging and disease
  • Knowledge of neurobiology

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Date Posted: 1/28/20

Full time/Non-exempt

How to apply

LABORATORY TECHNICIAN - WB2

Summary:
The full time Laboratory Technician will be responsible for the day to day operations of a basic science laboratory specializing in blood-brain barrier. This is an entry-level position, and the technician will be expected to quickly learn to conduct experiments on rats and mice both independently and in collaboration with others. The position also includes assisting with regulatory paperwork, animal protocols, ordering supplies, other aspects of lab maintenance, some administrative duties, basic statistical and pharmacokinetic analysis, and assisting with preparation of grants and scientific manuscripts.

Responsibilities:

  • Order supplies
  • Plan experiments
  • Label and purify radioactive ligands
  • Prepare tests and collect data per research protocol
  • Handle rats and mice, measure food intake, body weight, and collect tissue
  • Aspects of immunocytochemistry, fluorescence microscopy, and mouse breeding
  • Animal work will include: stereotaxic surgeries (for example controlled cortical impact), subcutaneous minipump implantations, small animal surgical techniques (isolation of carotid arteries), post-operative care and monitoring post-operative care and monitoring, brain dissections
  • Other duties as assigned

Position Requirements:

  • 1-3 years of experience working full-time in a basic science research lab setting
  • BS degree in biology, neuroscience, biochemistry or chemistry
  • Strong organizational, analytic, and communication skills

Knowledge and Experience:

  • Experience with small animal surgery and ability to handle rats and mice
  • Comfortable with handling low levels of radioactive materials
  • General lab skills

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Date Posted: 1/28/20

Full time/Non-exempt

How to apply

 

POSTDOCTORAL RESEARCHER - in vitro blood-brain barrier dysfunction (Erickson/Banks)

Summary:

This posting is for a postdoctoral position in the labs of Drs. Michelle A. Erickson and William A. Banks at the Seattle VA Medical Center and University of Washington. The scientific focus of the labs comprises many aspects of blood-brain barrier physiology that include peptide and protein transport, neuroimmune communication, and effects of disease states on blood-brain barrier functions. The candidate would be expected to support a project which aims to determine how circulating factors contribute to blood-brain barrier dysfunction in aging and Alzheimer’s disease. The candidate would also be encouraged to participate on other projects that align with their goals for career development. This position is supported by strong funding from the VA and NIH. The VA Medical Center and University of Washington offer a tremendous training environment for postdoctoral researchers interested in the fields of neuroscience, stem cell biology, aging, and Alzheimer’s disease.

Responsibilities:

  • Carry out technical aspects of research projects, which include designing and conducting experiments, recording and analyzing data, and communicating results to supervisors and the research group at least weekly
  • Maintain inventory of human induced pluripotent stem cell (iPSC) lines and human primary glial cell
  • Conduct routine differentiations of iPSCs into brain endothelial-like cells to support ongoing projects in the lab
  • Complete and stay current on all training required by the VA and affiliated institutions, adhere to all rules and regulations
  • Assist in the writing and submission of regulatory documents
  • Supervise junior investigators at undergraduate level or above
  • Apply for postdoctoral fellowships and/or career development awards such as those supported by the VA or NIH
  • Present data at scientific conferences
  • Prepare manuscripts on original research and write literature reviews
  • More detailed aspects of technical duties:
    • Maintain cell cultures, including iPSC lines and in vitro models of the blood-brain barrier, primary glia, etc.
    • Conduct pharmacokinetic studies of peptide and protein transport across the blood-brain barrier in vitro and in vivo
    • Dissect tissues and process tissue samples for analysis
    • Quantify levels of proteins and mRNA in tissues using procedures such as immunoblotting, ELISA, immunofluorescent analysis and microscopy, qPCR, etc.
    • Learn and apply new techniques (including SOPs) to ongoing projects.

Position Requirements:

  • Ph.D., M.D., or other doctoral degree with experience in neuroscience, pharmacology, physiology, immunology, or a related field in the biomedical sciences (degree must be completed by Fall 2020).
  • Eligible to work in the U.S. and to apply for T32/F32 funding
  • At least 3 years of cell culture experience, work with primary neuronal and glial cultures and/or iPSCs is preferred
  • Able to work with mice and radioactive isotopes
  • Able to work alternating weekends for tissue culture maintenance
  • Must work well with others, maintain meticulous records, be pro-active about seeking help when needed, and treat all lab members with respect
  • Experience with techniques such as RNAseq, proteomics, metabolomics, flow cytometry, 3D tissue culture, etc. is beneficial, but not strictly required.

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Date Posted: 2/4/2020

Full time/Non-exempt

How to apply

RESEARCH ASSISTANT - MIRECC

Summary:

This position works with the Northwest Mental Illness Research, Education, and Clinical Center (NW MIRECC) conducting world class biomedical research.

The NW MIRECC develops novel and improved treatments for major behavioral disorders afflicting veterans, directing major resources to support research, education, and treatment for neuropsychiatric disorders highly prevalent among combat-exposed returnees including posttraumatic stress disorder (PTSD) and blast concussive mild traumatic brain injury (mTBI). This position will interact with a multidisciplinary group of clinical and basic investigators, as well as other clinicians, social workers, fellows, volunteer research participants, community partners, scientific collaborators, and Department of Defense components, locally and nationally.

This position support translational neuroscience research; treatment of PTSD and trauma; treatment of common comorbidities such as repetitive blast mild traumatic brain injury (mTBI), alcohol use disorder (AUD), cannabis use disorders, chronic pain, and cognitive impairment; and design and implementation of clinical trials.

Responsibilities:
Under minimal supervision and guidance, the research study assistant will:

  • Schedule participant appointments and coordinate study activities with MIRECC staff
  • Assist with recruiting research volunteers
  • Create, modify, and maintain study data collection documents and files
  • Record, organize, verify, transcribe, and upload research study data
  • Prepare and organize regulatory materials for investigators and staff
  • Inventory and resupply study specific materials and kits
  • Participate in research study visits and procedures
  • Accompany study participants to various research procedures
  • Conduct vital signs, ECGs, psychometric testing, and phlebotomy
  • Use physiologic monitoring equipment, such as pupillometry and actigraphy
  • Process/test urine, blood, and cerebrospinal fluid (CSF)
  • Ship and track human biological samples
  • Maintain confidentiality of participant and study records at all times
  • Serve as protocol resource for participants and staff
  • Perform other related duties as needed

Position Requirements:

  • Bachelor’s degree
  • Authorized to work in the US

Desirable Skills:

  • Experience working with psychophysiology equipment and/or data
  • Ability to work independently
  • Strong interpersonal skills
    Solid problem-solving skills
  • Impeccable organizational and time management abilities
  • Able to adapt to changing research and staff priorities
  • Strong attention to detail
  • Previous experience in clinical research
  • Familiarity and experience with a veteran population
  • Willingness and ability to work flexible schedule to accommodate participants
  • Willingness to work at secondary site(s)

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Date Posted: 2/26/2020

Full time/Exempt

How to apply

BIOSTATISTICIAN

Seattle Institute for Biomedical and Clinical Research at the VA Puget Sound Health Care System has an outstanding opportunity for a master’s-level biostatistician to work with an experienced group of investigators committed to high-quality research at the Geriatric Research Education and Clinical Center (GRECC). This individual will support and collaborate with GRECC researchers on epidemiological, clinical, and genetic studies of neurodegenerative and psychiatric disorders (e.g., Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury). Primary scientific responsibilities will be the application of statistics to observational health research including the design, analysis, interpretation, and documentation phases.

Responsibilities:

  • Work with the senior PhD biostatistician, medical investigators, and research associates to design, analyze, and present/publish results of biomarker, epidemiological, and genetic studies related to neurodegenerative and psychiatric disorders.
  • Work with researchers to identify relevant research questions and appropriate analysis design.
  • Work with research associates to extract and create databases for statistical analysis.
  • Implement and program statistical software for data cleaning and data analysis.
  • Work with research associates and medical investigators to ensure high data quality.
  • Document, present, and explain statistical analyses.
  • Collaborate with GRECC researchers on manuscripts, posters, and other presentations of results.
  • Collaborate with GRECC researchers to identify new topics for investigation.

Qualifications:

  • MS degree in biostatistics, statistics, or a closely related field, and at least 3 years of experience.
  • Experience with research design, data collection, and data analysis.
  • Proficient in the statistical software package R. (Experience with SPSS and/or Python a plus.)
  • Excellent programming skills.
  • Proficient with MS EXCEL and MS Word.
  • Ability to work with a diverse group of researchers with varying levels of statistical and research experience.
  • Ability to work independently and with limited supervision.
  • Flexible with changing priorities and timelines.
  • Excellent verbal and written communication skills.
  • Strong interpersonal skills.
  • Experience in statistical genetics a plus.
  • Background in biological sciences a plus.

 

Date Posted: 3/11/2020

Full time/Exempt

How to apply

LABORATORY TECHNICIAN II - WB2

Summary:
The full time Laboratory Technician will be responsible for the day to day operations of a basic science laboratory specializing in blood-brain barrier. The technician will conduct experiments on rats and mice both independently and in collaboration with others and be responsible for the instruction and supervision of graduate students, post docs, and in some cases junior faculty. The position also includes writing animal protocols, ordering supplies, other aspects of lab maintenance, some administrative duties, basic statistical and pharmacokinetic analysis, and assisting with preparation of grants and scientific manuscripts.

Responsibilities:

  • Order supplies
  • Manage grant budget
  • Plan experiments
  • Label and purify radioactive ligands
  • Prepare tests and collect data per research protocol
  • Handle rats and mice, measure food intake, body weight, and collect tissue
  • Aspects of immunocytochemistry, fluorescence microscopy, and mouse breeding
  • Animal work will include: stereotaxic surgeries (for example controlled cortical impact), subcutaneous minipump implantations, small animal surgical techniques (isolation of carotid arteries), post-operative care and monitoring post-operative care and monitoring, brain dissections
  • Other duties as assigned

Position Requirements:

  • 3+ years of experience working full-time in a basic science research lab setting
  • BS degree in biology, neuroscience, biochemistry or chemistry
  • Strong organizational, analytic, and communication skills

Knowledge and Experience:

  • Experience with small animal surgery and ability to handle rats and mice
  • Comfortable with handling low levels of radioactive materials
  • General lab skills

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Date Posted: 3/20/2020

Full time/Exempt

How to apply

RESEARCH GRANTS MANAGER

Summary:
The Grants and Contracts Manager is responsible for the full pre- and post-award grants management process including preparation, submission, and management of a portfolio of applications and awards from external funding sources, including Federal, State, voluntary health agencies and foundations. This person also contributes to and supports Sponsored Programs team process improvement and management initiatives.

Qualifications:

• Bachelor’s degree.
• At least 3+ years of experience in an independent role managing federal grants.
• Database experience and knowledge of various electronic grant submission systems.
• Exceptional customer service skills dealing with both technical and professional staff in a collegial setting.
• Strong familiarity with federal rules, regulations and standards and the ability to effectively communicate this information to our investigators and staff.
• Ability to work as a team member with a high degree of reliability, accuracy and productivity.
• Must have high attention to detail and strong writing skills.
• Strong organization and time management skills and the ability to multi-task and organize work-load relative to deadlines in a highly detailed position.

Responsibilities:

• Assembles and submits a large volume and variety of grant proposals.
• Conducts a quality control review of all proposals before submission to ensure each application meets sponsor proposal requirements and SIBCR/VA policy requirements.
• Maintains knowledge of the submission and reporting requirements, including the electronic submission process, for various federal and non-federal funding agencies.
• Negotiates grants and contract terms and resolves issues with a high degree of customer service.
• Performs post-award management duties for a portfolio of diverse projects, overseeing the administrative aspects of reporting and reconciliation, subawarding, monitoring project bugets and status, and prior approval requirements.
• Liaises frequently with grant sponsors and serves in a pivotal role to provide guidance on the various sponsor rules and regulations to our investigators and staff.
• Researches federal statutes and regulations to ensure the institute remains in compliance with laws and government policies.
• Assists as needed with inter-agency reporting such as cross-institute effort reporting, FSRS reporting, federal regulatory assurance registration, clinicaltrials,gov, etc.
• Interacts collegially with the SIBCR Human Resources and Accounting for grants and contracts management purposes.
• Analyzes quality assurance review results to identify trends/opportunities for improvement in processes, tools, and communication to further enhance the service provided to our stakeholders.
• Work with the Director of Sponsored Programs to implement process improvements.

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Date Posted: 3/20/2020

Full time/Exempt

How to apply

RESEARCH GRANTS SPECIALIST

Summary:
The Grants and Contracts Specialist provides comprehensive support for the full lifecycle of research grants from federal and non-federal sources, under supervision and with support of more senior staff. This person also supports Sponsored Programs team process improvement and management initiatives.

Qualifications:

• Bachelor’s degree.
• 1-3 years of experience related to federal grant management and exposure to federal rules, regulations and standards and various electronic grant submission systems.
• Ability to work as a team player in a customer service oriented environment.
• Ability to work independently with a high degree of reliability and attention to detail.
• Strong organization and time management skills; ability to multi-task and organize work-load relative to deadlines.
• Strong oral and written communication skills; ability to communicate in an amiable, yet effective manner in a collegial setting.
• Skill in using MS Office and other standard computer-based tools.

Responsibilities:

• Coordinate the pre-award preparation of grant proposals and budgets to ensure they meet project sponsors’ and SIBCR internal guidelines.
• Maintain knowledge of the submission and reporting requirements, including electronic submission process, for various funding agencies.
• Coordinate the implementation of new awards to meet regulatory requirements.
• Administer subawards and personnel agreements to ensure compliance with federal regulations, sponsor regulations and internal guidelines.
• Monitor funded research activities to ensure they meet grantor agencies’ administrative and financial requirements including the timely submission of progress and financial reports.
• Maintain accurate records and grant files in accordance with regulatory requirements and internal procedures.
• Perform other related duties as assigned

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Date Posted: 3/26/2020

Full time/Non-Exempt

How to apply

POSTDOCTORAL CLINICAL RESEARCH FELLOW

Duties assigned to this title will require an in depth knowledge of a specialized field, process, or discipline and may involve organizing and implementing complex research plans, the development of methods of research, testing and data collection, analysis and evaluation, and writing reports containing descriptive, analytical, and evaluative content. The duties will require the exercise of independent discretion and judgment in carrying out research activities within the predetermined research scope and methodology.

Qualifications:

  • Knowledge of the principles and techniques of the subject disciplines.
  • Organizational and project management skills.
  • Written and oral communication skills.

Responsibilities:

  • The incumbent will be employed to carry out advanced independent and/or directed research to achieve the objectives of the research project.
  • At the time of employment, the responsible faculty member or principal investigator will establish the professional objectives and performance standards for the incumbent and will make annual evaluations.
  • Collect and analyze data, including periodical/literature search and utilizing specialized skills in related field to analyze the collected data.
  • Participate/assist in manuscript writing for publication in scientific journals and/or presentations. May also assist in grant writing.
  • Presentation of project results to internal and external parties.
  • Lab maintenance, including equipment maintenance, and ordering of supplies as needed.
  • Other duties as assigned, which may include attending Scientific Conferences and Meetings.

Position Requirements:

  • A doctoral degree in the appropriate field or discipline.
  • Must provide three professional references

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