SIBCR's mission is to improve the health and well-being of Veterans through research and education conducted at both the Seattle and Tacoma VA Puget Sound Health Care System. SIBCR is dedicated to supporting research and education efforts by facilitating collaborative research projects with other federal agencies, voluntary health organizations, nonprofit professional societies, academic institutions and for-profit companies.
SIBCR is an Equal Opportunity Employer. No phone calls please.
Date Posted: 1/6/2020
The laboratory of Brian Kraemer seeks a talented and enthusiastic postdoc who works well with others to join our multi-disciplinary collaborative research team at the Seattle Institute for Biomedical and Clinical Research (SIBCR). Dr. Kraemer is faculty at the University of Washington School of Medicine and his laboratory is located on the VA Medical Center Campus in Seattle, Washington. The Kraemer laboratory studies the molecular genetics of neurodegenerative diseases, including Alzheimer’s disease, frontotemporal lobar degeneration, and amyotrophic lateral sclerosis. This is a full time position working on a research project supported by an NIH funded R01 grant.
We offer: a highly stimulating and collaborative scientific work environment in a large laboratory with state of the art research equipment and cutting edge microscopy facilities. Opportunities for career development are readily available and include access to the NIH sponsored Alzheimer’s Disease and related dementia training program. This position includes full benefits and compensation at the NIH stipulated pay scale for postdocs. Seattle is a dynamic city in the Pacific Northwest with easy access to both the cascade mountains and Puget Sound. Additional information about the laboratory and research setting can be found here: https://sites.google.com/uw.edu/kraemerlab/home
- A PhD in a relevant field of the biomedical science.
- Experience designing and executing well controlled experiments.
- Strong writing skills.
- Strong verbal communication skills.
- Ability to work both independently and as a cooperative part of a team.
- Authorized to work in the US
Beneficial experience/knowledge/skills may include:
- Experience in genome editing using CRIPSR/Cas9 methods.
- Experience in molecular cloning and transgenesis methods
- Experience with genetic analysis methods in model organisms.
- Experience in assessing protein aggregation.
- Experience in advanced microscopy techniques.
- Knowledge of RNA binding protein function.
- Knowledge of the pathobiology of neurodegenerative disease
- Knowledge of the biology of aging and disease
- Knowledge of neurobiology
Date Posted: 1/28/20
This posting is for a postdoctoral position in the labs of Drs. Michelle A. Erickson and William A. Banks at the Seattle VA Medical Center and University of Washington. The scientific focus of the labs comprises many aspects of blood-brain barrier physiology that include peptide and protein transport, neuroimmune communication, and effects of disease states on blood-brain barrier functions. The candidate would be expected to support a project which aims to determine how circulating factors contribute to blood-brain barrier dysfunction in aging and Alzheimer’s disease. The candidate would also be encouraged to participate on other projects that align with their goals for career development. This position is supported by strong funding from the VA and NIH. The VA Medical Center and University of Washington offer a tremendous training environment for postdoctoral researchers interested in the fields of neuroscience, stem cell biology, aging, and Alzheimer’s disease.
- Carry out technical aspects of research projects, which include designing and conducting experiments, recording and analyzing data, and communicating results to supervisors and the research group at least weekly
- Maintain inventory of human induced pluripotent stem cell (iPSC) lines and human primary glial cell
- Conduct routine differentiations of iPSCs into brain endothelial-like cells to support ongoing projects in the lab
- Complete and stay current on all training required by the VA and affiliated institutions, adhere to all rules and regulations
- Assist in the writing and submission of regulatory documents
- Supervise junior investigators at undergraduate level or above
- Apply for postdoctoral fellowships and/or career development awards such as those supported by the VA or NIH
- Present data at scientific conferences
- Prepare manuscripts on original research and write literature reviews
- More detailed aspects of technical duties:
- Maintain cell cultures, including iPSC lines and in vitro models of the blood-brain barrier, primary glia, etc.
- Conduct pharmacokinetic studies of peptide and protein transport across the blood-brain barrier in vitro and in vivo
- Dissect tissues and process tissue samples for analysis
- Quantify levels of proteins and mRNA in tissues using procedures such as immunoblotting, ELISA, immunofluorescent analysis and microscopy, qPCR, etc.
- Learn and apply new techniques (including SOPs) to ongoing projects.
- Ph.D., M.D., or other doctoral degree with experience in neuroscience, pharmacology, physiology, immunology, or a related field in the biomedical sciences (degree must be completed by Fall 2020).
- Eligible to work in the U.S. and to apply for T32/F32 funding
- At least 3 years of cell culture experience, work with primary neuronal and glial cultures and/or iPSCs is preferred
- Able to work with mice and radioactive isotopes
- Able to work alternating weekends for tissue culture maintenance
- Must work well with others, maintain meticulous records, be pro-active about seeking help when needed, and treat all lab members with respect
- Experience with techniques such as RNAseq, proteomics, metabolomics, flow cytometry, 3D tissue culture, etc. is beneficial, but not strictly required.
Date Posted: 3/26/2020
Duties assigned to this title will require an in depth knowledge of a specialized field, process, or discipline and may involve organizing and implementing complex research plans, the development of methods of research, testing and data collection, analysis and evaluation, and writing reports containing descriptive, analytical, and evaluative content. The duties will require the exercise of independent discretion and judgment in carrying out research activities within the predetermined research scope and methodology.
- Knowledge of the principles and techniques of the subject disciplines.
- Organizational and project management skills.
- Written and oral communication skills.
- The incumbent will be employed to carry out advanced independent and/or directed research to achieve the objectives of the research project.
- At the time of employment, the responsible faculty member or principal investigator will establish the professional objectives and performance standards for the incumbent and will make annual evaluations.
- Collect and analyze data, including periodical/literature search and utilizing specialized skills in related field to analyze the collected data.
- Participate/assist in manuscript writing for publication in scientific journals and/or presentations. May also assist in grant writing.
- Presentation of project results to internal and external parties.
- Lab maintenance, including equipment maintenance, and ordering of supplies as needed.
- Other duties as assigned, which may include attending Scientific Conferences and Meetings.
- A doctoral degree in the appropriate field or discipline.
- Must provide three professional references
Date Posted: 4/23/2020
The Clinical Research Assistant will work as a key team member on a series of pulmonary studies based at the VA Puget Sound Health Care System. This position will require an individual who understands the principles of scientific investigation and clinical trials, is capable of in-depth understanding of the study protocol and is able to make complex decisions independently. The candidate must possess strong scientific, organizational, and interpersonal skills. A BA/BS or higher is required, with a degree in a science-related field strongly recommended. The position is full-time, Monday through Friday approximately 8:00 – 4:30 pm. The salary is based on the applicant’s research experience and includes benefits.
Responsibilities may include:
- Provide daily operational support
- Ensure compliance with applicable IRB, human subjects, and data security guidelines and regulations
- Support recruitment, screening, enrollment, consent, and follow-up of clinical trial participants according to study protocols, including:
- reviewing medical charts
- conducting study visits
- administering questionnaires
- measuring participant vital signs including height, weight, and blood pressure
- timely and accurate data entry
- preparing participant mailings
- tracking study activities
- Assist with development and maintenance of databases and files
- Prepare written reports and document procedures
- Assist with grant submissions, including preparing applications, conducting literature reviews, and other tasks as needed
- BA/BS and 2+ years of experience in human subjects health care research
- Outstanding organizational and communication skills
- Keen attention to detail
- Ability to work in a collaborative team environment
Desirable Knowledge and Experience:
- Experience with electronic medical record systems
- Knowledge of research compliance regulations
- Experience using Microsoft applications including Outlook, Word, Excel, and Access
- Experience using a reference manager